knuddz
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Themenstarter
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Hmm, vielleicht weil Homocystein und/oder Cystein zur Komplexbildun benötigt werden?
Although these findings are interesting, there may be an alternate species formed in vivo involving the binding of the vicinal thiols of a single molecule of DMPS or DMSA to a single inorganic mercuric ion. The potential species may involve the binding of the vicinal sulfur atoms of a single molecule of either DMPS or DMSA to a single inorganic mercuric ion, while the single sulfur atom of two molecules of Cys, Hcy, and/or GSH bind to the mercuric ion in a tetrahedral manner. Assuming that Cys and Hcy are present in plasma at concentrations of at least 10 μM82 and that the intracellular concentrations of GSH are in low millimolar concentrations,74,76,141–144 some form of thiol competition may promote intracellular formation of a mixed mercuric conjugate. From a purely chemical standpoint, the authors of the spectroscopic data suggest that DMPS and DMSA are not well optimized for chelation of Hg owing to the observation that neither compound forms a true chelate complex with mercury.140,145 A chelate has been defined as a stable ring complex formed by the binding of a metal ion with two or more functional groups of another molecule.140 Therefore, DMPS and DMSA may be best described as complexing agents. Both of these vicinal thiols have proven to be extremely effective in reducing the renal and plasma burden of Hg, which makes the compounds therapeutically effective despite not being optimized chelators.
Quelle
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