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Zink, Cadmium und Kupfer können den Vanilloidrezeptor auch aktivieren. Septembermond, hattest Du nicht geschrieben, dass Du Zink eingenommen und wohl nicht vertragen hast? Vielleich wäre folgende Studie eine mögliche Erklärung, warum:
https://www.ncbi.nlm.nih.gov/pubmed/20133428
Vollständiger Artikel:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774170/
Zink, Cadmium und Kupfer können den Vanilloidrezeptor auch aktivieren. Septembermond, hattest Du nicht geschrieben, dass Du Zink eingenommen und wohl nicht vertragen hast? Vielleich wäre folgende Studie eine mögliche Erklärung, warum:
J Appl Physiol (1985). 2010 Apr;108(4):891-7. doi: 10.1152/japplphysiol.01371.2009. Epub 2010 Feb 4.
Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1.
Gu Q1, Lin RL.
Author information
Abstract
Airway exposure to zinc dust and zinc-containing ambient particulates can cause symptoms of airway irritation and inflammation, but the underlying molecular and cellular mechanisms are largely unknown. Transient receptor potential A1 (TRPA1) is selectively expressed in a subpopulation of pulmonary C-fiber afferents and has been considered as a major irritant sensor in the lung and airways. Using whole cell patch-clamp recording and Ca(2+) imaging, we have demonstrated that application of ZnCl(2) concentration dependently evoked inward current and Ca(2+) transient in isolated vagal pulmonary sensory neurons; both responses were almost completely inhibited after pretreatment with AP18, a specific TRPA1 antagonist. In anesthetized spontaneously breathing animals, intratracheal instillation of ZnCl(2) (2 mM, 25 microl) induced pronounced respiratory depression in wild-type mice, and the effect was essentially absent in TRPA1-deficient mice. In addition, our study showed that two other heavy metals, cadmium and copper, also stimulated pulmonary sensory neurons via a direct activation of TRPA1. In summary, our results suggest that activation of TRPA1 in pulmonary C-fiber sensory nerves may contribute to the respiratory toxicity induced by airway exposure to these three heavy metals.
PMID:
20133428
PMCID:
PMC3774170
DOI:
10.1152/japplphysiol.01371.2009
https://www.ncbi.nlm.nih.gov/pubmed/20133428
Vollständiger Artikel:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774170/