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ElsevierProbiotics Raise Mortality Risk in Patients with Severe Pancreatitis
Using probiotic therapy to reduce infectious complications in severe pancreatitis actually increases mortality, according to a study released early by Lancet.
Dutch researchers randomized some 300 patients with first episodes of acute pancreatitis who were judged to be at risk for severe disease. Patients received a 28-day course of either placebo or a combination of Lactobacillus, Lactococcus, and Bifidobacterium species via feeding tube or later ingested orally. Treatment assignments were double-blinded.
By follow-up at 90 days, rates of infectious complications between the groups did not differ. However, those on probiotic therapy had mortality rates twice as high as those on placebo, and nine suffered bowel ischemia.
The authors speculate that increased oxygen demands of the infused bacteria may have led to the ischemia. Regardless of the cause, they conclude that "probiotics can no longer be considered to be harmless adjuncts to enteral nutrition, especially in critically ill patients."
Lancet article
Die bekommen Dir anscheinend nicht gerade toll. - Ich würde sie absetzen oder zumindest die Dosis radikal heruntersetzen (manche fangen mit Einreiben in die Armbeuge an) und andere Probiotika ausprobieren.Bei Symbioflor bekomme ich allerdings Herzzuckungen,Atennot-wobei gerade diese Bakterien enorm im Keller bei mir sind...