Molybdän

Themenstarter
Beitritt
26.11.05
Beiträge
22
Hi,

nachdem ich jetzt gerade die Hälfte meiner Füllungen geschafft habe, möchte ich Euch kurz folgenden Artikel nicht vorenthalten. Man bekommt Molybdän übrigens in der Apotheke.

"I've been sitting on a post about molybdenum for several weeks. As some
of you know, I suffered low-level mercury poisoning for several years
after a filling cracked. Molybdenum is a crucial trace mineral needed
for the synthesis of metallothionein, which moves heavy metals out
through the kidneys. Like several other conditions, mercury poisoning
can easily deplete the body's supply of molybdenum by overtaxing
metallothionein during detox.

Unfortunately, there's no readily available commercial test a doctor can
order to check for molybdenum deficiency and it's not exactly a mineral
you can safely overdose on when supplementing. This basically means you
have to check your symptoms and wing it, which I did with some success.
I'm currently taking about 300mcg of molybdenum daily - about twice what
the doctor recommended. I began with 150mcg and within hours of my
first dose, a couple of my symptoms improved dramatically. The itching
and flaking from minoxidil vanished. My allergies to mold improved as
did my fatigue. It was quite remarkable.

As I'll show in this posting, molybdenum is fundamental to many
metabolic processes yet poorly studied and rarely the focus of
professional medical treatment. Because I've heard people complaining
about some of these same symptoms over the years, I thought I'd outline
what you might experience with molybdenum deficiency, the role
molybdenum plays in the body and some of the scant recent research into
molybdenum. This should help give you any idea if it's worth trying.

You should consider molybdenum deficiency if you've had

+ metals poisoning

+ diabetes or insulin resistance

+ allergy/sensitivity to yeast/fungus/molds or foods with sulfites
(e.g., wine)

+ other mineral deficiencies (magnesium, zinc, copper, etc.)

+ intolerance to alcohol and/or alcohol sugars like sorbitol (either
ingested or applied topically); maybe even intolerance to propylene
glycol

+ unexplained inflammation or hormone overactivity/underactivity
(molybdenum is necessary for proper functioning of steroid and
glucocorticoid receptors)

+ problems with nitric oxide generation, low tetrahydrobiopterin(BH4)
or high homocysteine

+ oxidative stress (high lipid peroxide or TBARS)

+ chronic fungal infections like rhinitis (fungi convert sugars into
alcohol and can also generate formaldehyde, ammonia, acetaldehyde and
other toxic byproducts which are metabolized by molybdenum-containing
enzymes; molybdenum deficiency causes these byproducts to back up to
damaging levels)

+ unexplained chronic fatigue/insomnia

+ difficulties processing purines like adenosine

+ sugar/carb cravings

+ alcoholism

+ chemical sensitivities/intolerances (e.g., aldehydes accumulate in
the body from car exhaust, carpets, glues, cleaners and other parts of
modern living)

From academic sources and more informal conversations, I've pieced
together that molybdenum is directly or indirectly crucial for the
synthesis of aldehyde dehydrogenase, aldehyde oxidase, xanthine oxidase,
xanthine oxidoreductase, superoxide dismutase and BH4
(tetrahydrobiopterin).

Aldehyde dehydrogenase generates aldehydes and ketones from alcohol.
With adequate levels of molybdenum the body can metabolize alcohol and
acetaldehyde into Acetyl-CoA, a source of cellular energy (hence the
fatigue with molybdenum deficiency). It can also convert the sulfites
found in wines into taurine - which is why in a molybdenum-deficient
patient wine can cause headaches and other adverse reactions. In
general, folic acid, B12 and molybdenum - through various pathways and
with some assistance from glutamine - all help detoxify the ammonia
generated from sulfurous amino acids. A high homocysteine reading is a
good indication you've got a problem in this area. Excessive aldehydes
and ammonia may also screw up serotonin/tryptophan/B6 metabolism,
resulting in sleep disturbances, altered immunity and neurotransmitter
disruptions. (B6 is itself necessary for metabolizing aldehydes.)

Xanthine oxidoreductase catabolizes purines like adenosine. Superoxide
dismutase is an antioxidant enzyme which reduces superoxide to less
hazardous radicals. BH4 stabilizes the generation of nitric oxide from
arginine. Without adequate levels of BH4 - a condition common in
diabetics - the body generates hazardous levels of superoxide and
peroxynitrite instead of beneficial nitric oxide.

Over the years, I've outlined various conditions which involve
inadequate nitric oxide signaling (COPD, diabetes, menopause, fibrosis,
baldness - even Crohn's and IBD
<http://www.newscientist.com/channel/health/dn8759.html>) and new
treatments (PDE inhibitors/cGMP agonists like theophylline and viagra;
SOD mimetics). You may wish to review my past postings on the subject.
Just as magnesium deficiency can lead to lack of adequate nitric oxide
levels [PMIDs 15607643, 11425281], so too can molybdenum deficiency. In
summation, I believe it's time to consider this important trace
mineral's role in the body's oxidant/antioxidant balance and growth
hormone axis.


----- Notes -----


in diabetics, Mo supplementation improves lipid peroxide levels (xLDL),
triglycerides and cholesterol while boosting all sorts of antioxidant
enzymes [PMID 15193982]; Mo improves infection-fighting by the immune
system in diabetics [PMID 12686492]

Mo is important for progesterone and glucocorticoid (antiinflammatory)
signaling [PMID 15774497]; sodium molybdate stabilizes steroid hormone
receptors; molybdenum may have an inhibitory effect on androgen receptor
binding [PMID 4010286] and can sometimes block the AR from binding to
its DNA response elements; sodium molybdate inhibits the salt-induced
transformation of the receptor to a DNA-binding state but did not
inhibit DNA binding of the receptor transformed previously in the
absence of molybdate [PMID 6714164]; in other models, exogenous sodium
molybdate inhibits activation of estrogen and androgen receptors in rat
uterus and liver [PMID 8363596]; testosterone elevates levels of
aldehyde oxidase in the liver of rats and testosterone can give female
rats levels similar to male rats [PMID 10377246] (these are all
suggestive papers; I can't find any good, direct research on what
molybdenum intake does on steroid signaling in real humans)

Mo is very important to enzymes which metabolize carbohydrates [PMID
11834216].

Sodium molybdate (Na2Mo4) has a protective effect against the acute
toxicity of mercury chloride (HgCl2) in rats, encouraging the urinary
excretion of mercury and it improves kidney function compared to rats
who receive only the mercury exposure [PMID 2347021]

Mo rescues bacterial growth when it's inhibited by the presence of
mercury [PMID 10966396] (which connects oral mercury poisoning directly
with leaky gut syndrome; mercury kills the friendly bacteria protecting
the gut lining); rats placed in stressful situations had fewer gut
problems if they were fed water laced with probiotics (lactobacillus
helveticus and l. rhamnosus); chronic stress sensitizes the gut the
dietary allergens and makes the gut leaky, increasing the amount of
harmful bacteria sticking to the gut lining; these harmful bacteria also
infiltrated the mesenteric lymph nodes which drain fluid from the
intestine, thus the bad bacteria had entered the body and activated the
immune system; probiotics minimized the changes in chemical signaling
and prevented the bad bacteria from sticking and moving into the lymph
system probably because the good bacteria competed with the bad bacteria
for ecological space, dampening down the inflammatory response
<http://news.bbc.co.uk/1/hi/health/4938020.stm>

a diet high in sulfur- and sulfate-containing foods increases relapse in
the inflammatory bowel disease ulcerative colitis, perhaps because it
produces hydrogen sulfide which damages the inner lining of the gut,
making it more leaky and increasing cell turnover; such foods include
meat (especially red meat), eggs, alcohol, nuts, cheese, broccoli,
various animal protein and processed foods like bread, beer, sausages,
dried fruit; milk and other dairy products were not a problem
<http://www.sciencedaily.com/releases/2004/09/040916103144.htm> (see the
earlier reference to treating Crohn's with viagra)

oral theophylline (a PDE4 inhibitor/adenosine receptor antagonist) is
effective for patients with COPD [PMID 16456383]; theophylline blocks
TGF-B-driven fibrosis of lung fibroblasts partly via a cAMP/PKA pathway
[PMID 16430859]

a gene (GCN2) that tells mice to eat a well-balanced diet and yeast to
make bread rise also selectively silences the immune system; GCN2
responds to low amino acid levels; GCN2 is a nutrition sensor in yeast
telling it it has enough nutrients to grow; indoleamine 2,3-dioxygenase
(IDO) is expressed in the GI tract and tonsils where the immune system
regularly meets foreign substances it might need to ignore; IDO protects
the fetus from rejection during pregnancy; tumors and persistent viruses
can hijack the IDO mechanism to hide from attack; IDO degrades
tryptophan which is essential to T-cell survival; this doesn¹t kill the
T-cell but does render it selectively non-responsive; the T-cells in
GCN2 knockout mice ignore IDO so GCN2 is necessary for immune tolerance
<http://www.sciencedaily.com/releases/2005/05/050518103418.htm>; IDO
represses the immune system by degrading tryptophan (the precursor to
serotonin) which is important to the function of T-cells; tumors can
recruit IDO secreting dendritic cells to protect themselves from the
immune system
<http://www.sciencedaily.com/releases/2004/07/040716081345.htm>


Print references

Carper, Jean, The Food Pharmacy, Bantam, 1988.

Chaitow, Leon, D.O., N.D., Amino Acids in Therapy, Healing Arts Press,
1988.

Mindell, Earl, Vitamin Bible, Warner, 1991.

Murray, Richard, D.C., Lactose, Institute of Practical Biochemistry 1:
1, part B.

Schmitt, Walter, Jr., D.C.,Molybdenum for candida albicans patients and
other problems, Digest of Chiropractic Economics 31: 4, Jan-Feb, 1991.

Schmitt, Walter, Jr., D.C., The clorox test: a screening device for free
radical pathology, Digest of Chiropractic Economics 30:2 & 30:3,
Sept-Oct, Nov-Dec, 1987."
 
Beitritt
10.01.04
Beiträge
66.908
Hier eine Kurz-Kurz-Zusammenfassung über Molybdän:
Molybdän - Mo

Der Bestand an Moblybdän im Körper ist ca. 10mg. 60% befinden sich im Skelett, 20% in der Leber, der Rest in den Zähnen, Nieren und der Haut. Es ist an wichtigen Enzymreaktionen im Körper beteiligt, bei denen z.B. die Energie aus Nahrungsfetten und Kohlenhydraten gewonnen wird. Molybdän ist entscheidend am Aufbau der Harnsäure beteiligt, welche als kräftiges Antioxidans und als Fänger von hochreaktiven freien Radikalen gilt.

Außerdem ist Molybdän ein lebenswichtiger Teil des Enzyms, das für die Eisenverwertung verantwortlich ist. Zudem ist Molybdän entscheidend für den Abbau von schwefelhaltigen Verbindungen bzw. von toxischen Sulfiten zu Sulfaten. Durch die industrielle Verarbeitung von Lebensmitteln geht ein erheblicher Anteil an Molybdän verloren.

Ursachen von Mangelzuständen
- Darmerkrankungen
- Zufuhrmangel

Symptome von Mangelzuständen
- Abbauprobleme von schwefelhaltigen Nahrungsmitteln und Aminosäuren
- gewisse Krebsformen
- Haarausfall
- Karies
- Müdigkeit
- Nierensteine
- Niedrige Harnsäure im Blut
- Sulfitallergien

Mögliche Anwendungsgebiete
- Allergie
- Asthma
- Sulfitentgiftung
- Krebs
- Karies
- Diabetes
- Dysbakterie
- Tumore

Natürliches Vorkommen
Bohnen, Hefe, Kartoffeln, Kohl, Leber, Linsen, Niere, Reis,
Sojamehl
http://www.pureinfo.at/lexikon/uebersicht.php?we_objectID=316

Uta
 

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Beitritt
10.01.04
Beiträge
66.908
Die Firma Pure Encapsulations ist gerade verkauft worden:
http://www.prnewswire.lu/cgi/news/release?id=118501
... Ferner steht die Atrium Biotechnologies Inc. zu 62 % im Eigentum von AEterna.

Aktien der AEterna sind an der Börse von Toronto (AEL) und am NASDAQ National Market (AELA) notiert. Pressemitteilungen und zusätzliche Informationen über AEterna können im Internet unter www.aeterna.com abgerufen werden.

Zukunftsweisende Aussagen

Diese Pressemitteilung enthält zukunftsweisende Aussagen gemäss den "Safe Harbour"-Vorschriften des US-amerikanischen Securities Litigation Reform Act von 1995. Zukunftsweisende Aussagen umfassen bekannte und unbekannte Risiken sowie Unabwägbarkeiten, aufgrund derer die aktuellen Ergebnisse des Unternehmens von den prognostizierten Ergebnissen erheblich abweichen können. Zu diesen Risiken und Unabwägbarkeiten zählen u. a. die Verfügbarkeit von Geldmitteln und Ressourcen, um FuE-Projekte durchzuführen, die erfolgreiche und zeitgerechte Fertigstellung von klinischen Studien, die Fähigkeit des Unternehmens, Vorteile aus den Geschäftschancen der Pharmaindustrie zu ziehen, Unabwägbarkeiten im Zusammenhang mit den aufsichtrechtlichen Prozessen und allgemeine Veränderungen der wirtschaftlichen Verhältnisse. Zusätzliche Informationen über Risiken und Unabwägbarkeiten bezüglich zukunftsweisender Aussagen finden Investoren in den bei den kanadischen und US-amerikanischen Börsenaufsichtsbehörden eingereichten vierteljährlichen und jährlichen Berichten des Unternehmens. Investoren wird nahe gelegt, nicht auf diese zukunftsweisenden Aussagen zu vertrauen. Das Unternehmen ist nicht verpflichtet, diese zukunftsweisenden Aussagen zu aktualisieren.
DAs klingt nicht unbedingt verheißungsvoll, was die bisher unbestrittene Qualität der Mittel von Pure Encapsulations angeht :confused: .

Gruss,
Uta
 
Beitritt
16.02.05
Beiträge
1.842
Ich leg mal ne Spur aus...

MOLYBDENUM AND COPPER: Molybdenum and copper are antagonists. Just as iron and molybdenum are synergists, iron and copper are antagonists if they are not in balance with each other, so are molybdenum and copper antagonists.
In patients who demonstrate copper toxicity patterns, we have traditionally employed zinc and manganese to chelate the excess copper out of the tissues. Molybdenum is also useful for this purpose. Molybdenum antagonizes copper absorption and in a number of experiments in animals, copper and molybdenum have been shown to be directly antagonistic to each other.
aus The Art of Getting Well
 

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