Tilt-Vasculitis
In the chemically sensitive patient, vascular injury associated with chemical insults manifests in a variety of signs and symptoms. The clinical picture is mainly dependent upon the types of vessels involved (vein, capillary, or large or small artery), the numbers of vessels involved, the intensity and duration of the pollutant stimuli present, and the strength of the nutrient-derived vessel repair mechanisms. The spectrum of injury can range from a very mild localized edema to a major end-organ failure with loss of limb or organs or life to any problems in between. Problems may develop over a long period of time or within a relatively short period.
The clinical syndromes produced by pollutants are myriad. Some are named and others are not. Discussed separately are small vessel vasculitis, large vessel vasculitis, carotid spasm, Raynaud’s disease, hypertension, specific systemic undifferentiated Tilt-hypersensitive vasculitis , Panarteriitis nodosa, Wegener’s granulomatosis, rheumatoid vasculitis, recurrent phlebitis and thrombophlebitis, thrombosis etc.
„Many necrotizing and non-necrotizing vasculitides are directly caused or closely associated with immunopathogenic mechanism and environmental triggers. It was originally thought that the mechanism most commonly associated with Vasculitis is that of the deposition of circulating immune complexes in the blood vessel walls. However, this association appears to be limited since complexes are not always necessary for inflammation of vessels to occur. In fact, a larger percentage of blood vessels deregulation in the chemically sensitive patient appears to occur through non-immune mechanism.”